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- Title
Longitudinal patterns of urine biomarkers in infants across gestational ages.
- Authors
DeFreitas, Marissa; Seeherunvong, Wacharee; Katsoufis, Chryso; RamachandraRao, Satish; Duara, Shahnaz; Yasin, Salih; Zilleruelo, Gaston; Rodriguez, Maria; Abitbol, Carolyn
- Abstract
Background: Urinary biomarkers may be indicators of acute kidney injury (AKI), although little is known of their developmental characteristics in healthy neonates across a full range of gestational age (GA). The purpose of this study was to examine patterns of urinary biomarkers across GA groups from birth to 3 months of age. Methods: Fifty-two infants ranging from 24 to 41 weeks' GA had urine assayed from birth through 3 months of age for 7 biomarkers including albumin (ALB), beta-2-microglobulin (B2M), cystatin-C (CysC), epidermal growth factor (EGF), neutrophil-gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and uromodulin (UMOD). Results: Of the seven urinary biomarkers, EGF and UMOD increased while others decreased with advancing GA. By 3 months of age, EGF and UMOD had increased in preterm infants to levels similar to those of term infants. UMOD/ml and EGF/ml appeared to be predominantly developmental biomarkers distinguishing estimated glomerular filtration rate (GFR) <30 ml/min/1.73 m with receiver operator characteristic area under the curve (ROC-AUC) of 0.82; p = 0.002. When factored by urine creatinine CysC/cr + ALB/cr were the most significant functional markers with AUC = 0.79; p = 0.004; sensitivity 96 %; specificity 58 %. Conclusions: Among healthy neonates, urinary biomarkers vary with GA. These data support the use of urinary biomarkers in the assessment of normal kidney development in the absence of injury.
- Subjects
ACUTE kidney failure; AGE distribution; BIOMARKERS; BLOOD proteins; CARRIER proteins; CONFIDENCE intervals; STATISTICAL correlation; CREATININE; CYTOKINES; EPIDERMAL growth factor; FISHER exact test; GESTATIONAL age; GLOBULINS; GLOMERULAR filtration rate; GLYCOPROTEINS; LONGITUDINAL method; PROBABILITY theory; RESEARCH funding; STATISTICS; T-test (Statistics); PILOT projects; DATA analysis; MULTIPLE regression analysis; ALBUMINS; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; KRUSKAL-Wallis Test; ONE-way analysis of variance; CHILDREN; DIAGNOSIS
- Publication
Pediatric Nephrology, 2016, Vol 31, Issue 7, p1179
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-016-3327-3