We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sars-CoV2 infection in pregnant women with multiple sclerosis.
- Authors
Aprea, Maria Grazia; Schiavetti, Irene; Portaccio, Emilio; Ballerini, Chiara; Battaglia, Mario Alberto; Bergamaschi, Roberto; Brichetto, Giampaolo; Bunul, S Destan; Calabrese, Massimiliano; Capobianco, Marco; Cavalla, Paola; Celani, Maria Grazia; Clerico, Marinella; Cocco, Eleonora; Comi, Giancarlo; Confalonieri, Paolo; Conte, Antonella; Cordioli, Cinzia; De Luca, Giovanna; De Rossi, Nicola
- Abstract
Background: In the general population, maternal SARS-CoV-2 infection during pregnancy is associated with worse maternal outcomes; however, only one study so far has evaluated COVID-19 clinical outcomes in pregnant and postpartum women with multiple sclerosis, showing no higher risk for poor COVID-19 outcomes in these patients. Objective: In this multicenter study, we aimed to evaluate COVID-19 clinical outcomes in pregnant patients with multiple sclerosis. Methods: We recruited 85 pregnant patients with multiple sclerosis who contracted COVID-19 after conception and were prospectively followed-up in Italian and Turkish Centers, in the period 2020-2022. A control group of 1354 women was extracted from the database of the Multiple Sclerosis and COVID-19 (MuSC-19). Univariate and subsequent logistic regression models were fitted to search for risk factors associated with severe COVID-19 course (at least one outcome among hospitalization, intensive care unit [ICU] admission and death). Results: In the multivariable analysis, independent predictors of severe COVID-19 were age, body mass index ⩾ 30, treatment with anti-CD20 and recent use of methylprednisolone. Vaccination before infection was a protective factor. Vaccination before infection was a protective factor. Pregnancy was not a risk nor a protective factor for severe COVID-19 course. Conclusion: Our data show no significant increase of severe COVID-19 outcomes in patients with multiple sclerosis who contracted the infection during pregnancy.
- Subjects
MULTIPLE sclerosis; PREGNANT women; SARS-CoV-2; COVID-19 pandemic; COVID-19
- Publication
Multiple Sclerosis Journal, 2023, Vol 29, Issue 9, p1090
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585231176174