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- Title
Predictive Clinical Parameters and Glycemic Efficacy of Vildagliptin Treatment in Korean Subjects with Type 2 Diabetes.
- Authors
Jin-Sun Chang; Juyoung Shin; Hun-Sung Kim; Kyung-Hee Kim; Jeong-Ah Shin; Kun-Ho Yoon; Bong-Yun Cha; Ho-Young Son; Jae-Hyoung Cho
- Abstract
Background: The aims of this study are to investigate the glycemic efficacy and predictive parameters of vildagliptin therapy in Korean subjects with type 2 diabetes. Methods: In this retrospective study, we retrieved data for subjects who were on twice-daily 50 mg vildagliptin for at least 6 months, and classified the subjects into five treatment groups. In three of the groups, we added vildagliptin to their existing medication regimen; in the other two groups, we replaced one of their existing medications with vildagliptin. We then analyzed the changes in glucose parameters and clinical characteristics. Results: Ultimately, 327 subjects were analyzed in this study. Vildagliptin significantly improved hemoglobin Atc (HbAlc) levels over 6 months. The changes in HbAlc levels (ΔHbAlc) at month 6 were -2.24% (P=0.000), -0.77% (P=0.000), -0.80% (P=0.001), -0.61% (P=0.000), and -0.34% (P=0.025) for groups 1, 2, 3, 4, and 5, respectively, with significance. We also found significant decrements in fasting plasma glucose levels in groups t, 2,3, and 4 (P<0.05). Of the variables, initial HbAlc levels (P= 0.032) and history of sulfonylurea use (P= 0.026) were independently associated with responsiveness to vildagliptin treatment. Conclusion: Vildagliptin was effective when it was used in subjects with poor glycemic control. It controlled fasting plasma glucose levels as well as sulfonylurea treatment in Korean type 2 diabetic subjects.
- Subjects
TYPE 2 diabetes treatment; GLYCEMIC index; GLUCOSE; HEMOGLOBINS; SULFONYLUREAS
- Publication
Diabetes & Metabolism Journal, 2013, Vol 37, Issue 1, p72
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2013.37.1.72