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- Title
Elevated Lipoprotein-Associated Phospholipase A<sub>2</sub> Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort.
- Authors
Yoo, Hye Jin; Kim, Minjoo; Lee, Sang-Hyun; Lee, Jong Ho
- Abstract
Inflammatory markers are susceptible to changes over time. Thus, we observed changes in inflammatory markers correlating with age-related increases in blood pressure (BP) through a prospective study. The aim of this study was to investigate changes in inflammatory markers that correlate with age-related increases in BP. The study included 1,500 nondiabetic and normotensive healthy subjects at baseline. Of these, 121 individuals who developed hypertension (defined as systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) after 2 years formed the hypertension group. For each incident hypertension case, 2 age- and sex-matched control subjects were selected among those who did not develop hypertension (control group, n = 242). After baseline adjustment, the hypertension group exhibited greater increases in body mass index (BMI), systolic and diastolic BP, triglyceride, total cholesterol, glucose, Lp-PLA2 activity, and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) levels compared to the control group. In the hypertension group, changes in (Δ) systolic BP correlated positively with Δ Lp-PLA2 activity, which correlated positively with Δ low-density lipoprotein (LDL−) cholesterol and Δ urinary 8-epi-PGF2α levels. Moreover, multiple linear regression revealed baseline systolic BP and Δ Lp-PLA2 activity to be independent predictors of Δ systolic BP in the hypertension group. Our results suggest that age-related increases in systolic BP may correlate strongly with elevated Lp-PLA2 activity and that Lp-PLA2 can be considered a biomarker for systolic BP elevation.
- Subjects
SOUTH Korea; AGE distribution; BIOMARKERS; BLOOD pressure; CHOLESTEROL; STATISTICAL correlation; ESTERASES; HYPERTENSION; INFLAMMATION; LIPOPROTEINS; LONGITUDINAL method; PROSTAGLANDINS; SEX distribution; TRIGLYCERIDES; MULTIPLE regression analysis; BODY mass index; CASE-control method; DISEASE complications
- Publication
International Journal of Hypertension, 2020, p1
- ISSN
2090-0384
- Publication type
Article
- DOI
10.1155/2020/5693271