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- Title
Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice.
- Authors
Walton, Chase M.; Saito, Erin R.; Warren, Cali E.; Larsen, John G.; Remund, Nicole P.; Reynolds, Paul R.; Hansen, Jason M.; Bikman, Benjamin T.
- Abstract
Yerba maté, a herbal tea derived from Ilex paraguariensis, has previously been reported to be protective against obesity-related and other cardiometabolic disorders. Using high-resolution respirometry and reverse-phase high-performance liquid chromatography, the effects of four weeks of yerba maté consumption on mitochondrial efficiency and cellular redox status in skeletal muscle, adipose, and liver, tissues highly relevant to whole-body metabolism, were explored in healthy adult mice. Yerba maté treatment increased the mitochondrial oxygen consumption in adipose but not in the other examined tissues. Yerba maté increased the ATP concentration in skeletal muscle and decreased the ATP concentration in adipose. Combined with the observed changes in oxygen consumption, these data yielded a significantly higher ATP:O2, a measure of mitochondrial efficiency, in muscle and a significantly lower ATP:O2 in adipose, which was consistent with yerba maté-induced weight loss. Yerba maté treatment also altered the hepatic glutathione (GSH)/glutathione disulfide (GSSG) redox potential to a more reduced redox state, suggesting the treatment's potential protective effects against oxidative stress and for the preservation of cellular function. Together, these data indicate the beneficial, tissue-specific effects of yerba maté supplementation on mitochondrial bioenergetics and redox states in healthy mice that are protective against obesity.
- Subjects
OBESITY; CARDIOVASCULAR diseases risk factors; GLUTATHIONE; FUNCTIONAL foods; HERBAL medicine; MEDICINAL plants; SKELETAL muscle; ANIMAL experimentation; LIQUID chromatography; OXYGEN consumption; CELL physiology; DIETARY supplements; MITOCHONDRIA; OXIDATIVE stress; T-test (Statistics); WEIGHT loss; DESCRIPTIVE statistics; RESEARCH funding; PLANT extracts; DATA analysis software; MICE; ADIPOSE tissues
- Publication
Nutrients, 2023, Vol 15, Issue 20, p4454
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15204454