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- Title
The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Authors
Camacho-Díaz, Brenda Hildeliza; Arenas-Ocampo, Martha Lucía; Osorio-Díaz, Perla; Jiménez-Aparicio, Antonio Ruperto; Alvarado-Jasso, Guadalupe Monserrat; Saavedra-Briones, Edén Valfré; Valdovinos-Díaz, Miguel Ángel; Gómez-Reyes, Elisa
- Abstract
Irritable bowel syndrome displays three different subtypes: constipation (IBS-C), diarrhea (IBS-D), and mixed (IBS-M). Treatment with dietary fiber is used, with consideration given both to the chemical composition of the fiber and to the different subtypes of IBS. The IBS-D subtype is usually treated with a low-FODMAPs diet, whereas the IBS-C subtype suggests prebiotics and probiotics to promote microbiota restoration. The aim of this study was to assess the effects of employing agave fructans as the soluble fiber of a jelly (Gelyfun®gastro) containing 8 g per serving in the IBS-C group (n = 50), using a randomized, double-blind, time-limited trial for four weeks. We evaluated changes in the frequency and types of bowel movements through the Bristol scale, and the improvement of the condition was evaluated using quality of life (IBS-QOL) and anxiety–depression (HADS) scales. The main results were that the number of bowel movements increased by more than 80%, with at least one stool per day from fifteen days onwards, without a laxative effect for the group treated. Finally, the quality of life with the prebiotic jelly was significantly improved compared to the placebo in all specific domains, in addition to significantly reducing anxiety and depression.
- Subjects
POLYSACCHARIDES; FUNCTIONAL foods; MEDICINAL plants; PREBIOTICS; IRRITABLE colon; CONSTIPATION; DEFECATION; RANDOMIZED controlled trials; PLACEBOS; COMPARATIVE studies; RESEARCH funding; BLIND experiment; QUALITY of life; MENTAL depression; STATISTICAL sampling; ANXIETY
- Publication
Nutrients, 2023, Vol 15, Issue 16, p3526
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15163526