We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of Selenium-Enriched Lactobacillus paracasei , Selenium-Enriched Yeast, and Selenite for the Alleviation of DSS-Induced Colitis in Mice.
- Authors
Zhong, Yuqing; Jin, Yan; Zhang, Qiuxiang; Mao, Bingyong; Tang, Xin; Huang, Jie; Guo, Renmei; Zhao, Jianxin; Cui, Shumao; Chen, Wei
- Abstract
Patients with inflammatory bowel disease (IBD) have been found to have decreased immune function. Selenium (Se) is an essential trace element that is beneficial for human health, which has a significant stimulating effect on immune function. We compared the effects of different Se forms on the alleviation of colitis in DSS-induced mice. Moreover, we also aimed to determine whether Se-enriched Lactobacillus paracasei CCFM 1089 could be used as a new organic Se supplement. Different Se supplements (Se-enriched L. paracasei CCFM 1089, Se-enriched yeast and sodium selenite) were given to Se-deficient mice suffering from colitis. Se-enriched L. paracasei CCFM 1089, which is based on selenocysteine (SeCys), had similar effects in terms of reducing oxidative stress and inhibiting pro-inflammatory factors to Se-enriched yeast; however, selenase activity in the Se-enriched L. paracasei CCFM 1089-treated mice was higher than that in other treatment groups. In addition, Se-enriched L. paracasei CCFM 1089 could better protect the intestinal mucosa, which increased the expression of tight junction proteins (ZO-1 and occludin) in mice. Thus Se-enriched L. paracasei CCFM 1089 was shown to alleviate IBD, suggesting that it has potential as a good organic Se supplement.
- Subjects
ANIMAL experimentation; SELENIUM compounds; YEAST; OXIDATIVE stress; COMPARATIVE studies; COLITIS; LACTOBACILLUS; INFLAMMATORY mediators; INTESTINAL mucosa; SELENIUM; INTESTINES; MICE; PHARMACODYNAMICS
- Publication
Nutrients, 2022, Vol 14, Issue 12, p2433
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14122433