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- Title
The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized Placebo-Controlled Trial.
- Authors
Razny, Urszula; Goralska, Joanna; Calder, Philip C.; Gruca, Anna; Childs, Caroline E.; Kapusta, Maria; Slowinska-Solnica, Krystyna; Dembinska-Kiec, Aldona; Solnica, Bogdan; Malczewska-Malec, Malgorzata
- Abstract
Weight loss contributes to an increased risk of hip fracture, especially in postmenopausal women. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation could diminish the adverse effect of weight loss on bone health. The aim of this randomized, placebo-controlled, double-blind parallel trial was to investigate the effect of caloric restriction and n-3 PUFA supplement intake on osteogenic markers (carboxylated osteocalcin (Gla-OC); procollagen I N-terminal propeptide (PINP)), as well as a bone resorption marker (C-terminal telopeptide of type I collagen (CTX-I)) in a serum of 64 middle aged individuals (BMI 25–40 kg/m2) with abdominal obesity. Bone remodeling, metabolic and inflammatory parameters and adipokines were determined before and after 3 months of an isocaloric diet (2300–2400 kcal/day) or a low-calorie diet (1200 kcal/day for women and 1500 kcal/day for men) along with n-3 PUFA (1.8 g/day) or placebo capsules. CTX-I and adiponectin concentrations were increased following 7% weight loss independently of supplement use. Changes in CTX-I were positively associated with changes in adiponectin level (rho = 0.25, p = 0.043). Thus, an increase in serum adiponectin caused by body weight loss could adversely affect bone health. N-3 PUFAs were without effect.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; DIET in disease; BIOMARKERS; OBESITY; ADIPOKINES; BONE growth; BODY weight; BONE resorption; DIET therapy; DIETARY supplements; TREATMENT effectiveness; RANDOMIZED controlled trials; COMPARATIVE studies; PRE-tests &; post-tests; BLIND experiment; BONE remodeling; ADIPONECTIN; WEIGHT loss; BONE density; STATISTICAL sampling; INFLAMMATORY mediators; MIDDLE age
- Publication
Nutrients, 2021, Vol 13, Issue 9, p3096
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13093096