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- Title
Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical.
- Authors
Boyer-Diaz, Zoe; Morata, Paloma; Aristu-Zabalza, Peio; Gibert-Ramos, Albert; Bosch, Jaime; Gracia-Sancho, Jordi
- Abstract
Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data.
- Subjects
ANTIOXIDANTS; CHRONIC diseases; INFLAMMATION; CIRRHOSIS of the liver; LIVER diseases; PORTAL hypertension; FUNCTIONAL foods; DOCOSAHEXAENOIC acid; OXIDATIVE stress; FIBROSIS
- Publication
Nutrients, 2020, Vol 12, Issue 9, p2627
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12092627