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- Title
Dietary Fish and Long-Chain n-3 Polyunsaturated Fatty Acids Intake and Risk of Atrial Fibrillation: A Meta-Analysis.
- Authors
Fu-Rong Li; Guo-Chong Chen; Jiabi Qin; Xianbo Wu
- Abstract
Findings on the association between long-term intake of fish or long-chain n-3 polyunsaturated fatty acids (PUFAs) and risk of atrial fibrillation (AF) are inconsistent in observational studies. We conducted a meta-analysis of prospective studies to separately examine the associations between fish consumption and dietary intake of n-3 PUFAs with the risk of AF. A systematic search was conducted in PubMed and Embase to identify relevant studies. Risk estimates were combined using a random-effect model. Seven prospective cohort studies covering 206,811 participants and 12,913 AF cases were eligible. The summary relative risk of AF for the highest vs. lowest category of fish consumption and dietary intake of n-3 PUFAs was 1.01 (95% confidence interval: 0.94-1.09) and 1.03 (95% confidence interval: 0.97-1.09), respectively. These null associations persisted in subgroup and dose-response analyses. There was little evidence of publication bias. This meta-analysis suggests that neither long-term intake of fish, nor of n-3 PUFAs were significantly associated with lower risk of AF.
- Subjects
ATRIAL fibrillation; CONFIDENCE intervals; FISHES; GRAIN; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; OMEGA-3 fatty acids; ONLINE information services; RELATIVE medical risk; PUBLICATION bias; DESCRIPTIVE statistics
- Publication
Nutrients, 2017, Vol 9, Issue 9, p955
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu9090955