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- Title
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery.
- Authors
Lu, Kun Ping; Zhou, Xiao Zhen
- Abstract
Protein phosphorylation is one of the most common mechanisms regulating cellular signaling pathways, and many kinases and phosphatases are proven drug targets. Upon phosphorylation, protein functions can be further regulated by the distinct isomerase Pin1 through cis-trans isomerization. Numerous protein targets and many important roles have now been elucidated for Pin1. However, no tools are available to detect or target cis and trans conformation events in cells. The development of Pin1 inhibitors and stereo- and phospho-specific antibodies has revealed that cis and trans conformations have distinct and often opposing cellular functions. Aberrant conformational changes due to the dysregulation of Pin1 can drive pathogenesis but can be effectively targeted in age-related diseases, including cancers and neurodegenerative disorders. Here, we review advances in understanding the roles of Pin1 signaling in health and disease and highlight conformational regulation as a distinct signal transduction checkpoint in disease development and treatment.
- Subjects
DRUG discovery; CELL communication; PHOSPHORYLATION; CELL physiology; CELLULAR signal transduction; PROTEIN microarrays
- Publication
Science Signaling, 2024, Vol 17, Issue 841, p1
- ISSN
1945-0877
- Publication type
Article
- DOI
10.1126/scisignal.adi8743