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- Title
Design and Implementation of a Nationwide Population-Based Longitudinal Survey of SARS-CoV-2 Infection in Spain: The ENE-COVID Study.
- Authors
Pastor-Barriuso, Roberto; Pérez-Gómez, Beatriz; Oteo-Iglesias, Jesús; Hernán, Miguel A.; Pérez-Olmeda, Mayte; Fernández-de-Larrea, Nerea; Molina, Marta; Fernández-García, Aurora; Martín, Mariano; Cruz, Israel; Sanmartín, José L.; León-Paniagua, José; Muñoz-Montalvo, Juan F.; Blanco, Faustino; Yotti, Raquel; Pollán, Marina
- Abstract
Data System. The Spanish National Seroepidemiological Survey of SARS-CoV-2 (or ENE-COVID; SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2] is the causative agent of COVID-19) was funded by the Spanish Ministry of Health, the Instituto de Salud Carlos III, and the Spanish National Health System. Data Collection/Processing. A stratified 2-stage probability sampling was used to select a representative cohort of the noninstitutionalized population of Spain. ENE-COVID collected longitudinal data from epidemiological questionnaires and 2 SARS-CoV-2 IgG antibody tests. From April 27 to June 22, 2020, 68 287 participants (77.0% of contacted persons) received a point-of-care test and 61 095 (68.9%) also underwent a laboratory immunoassay. A second follow-up phase was conducted between November 16 and 30, 2020. Data Analysis/Dissemination. Analyses use weights to adjust for oversampling and nonresponse and account for design effects of stratification and clustering. ENE-COVID data for research purposes will be available upon request from the official study Web page. Public Health Implications. ENE-COVID, a nationwide population-based study, allowed monitoring seroprevalence of antibodies against SARS-CoV-2 at the national and regional levels, providing accurate figures by gender, age (from babies to nonagenarians), and selected risk factors; characterizing symptomatic and asymptomatic infections; and estimating the infection fatality risk during the first pandemic wave. (Am J Public Health. 2023;113(5):525–532. https://doi.org/10.2105/AJPH.2022.307167)
- Subjects
SPAIN; PUBLIC health surveillance; VIRAL antibodies; HUMAN services programs; QUESTIONNAIRES; IMMUNOGLOBULINS; SEX distribution; AGE distribution; LONGITUDINAL method; RESEARCH; POINT-of-care testing; IMMUNOASSAY; SEROPREVALENCE; COVID-19 pandemic; EPIDEMIOLOGICAL research; EVALUATION
- Publication
American Journal of Public Health, 2023, Vol 113, Issue 5, p525
- ISSN
0090-0036
- Publication type
Article
- DOI
10.2105/ajph.2022.307167