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- Title
Critical Need for Family-Based, Quasi-Experimental Designs in Integrating Genetic and Social Science Research.
- Authors
D'Onofrio, Brian M.; Lahey, Benjamin B.; Turkheimer, Eric; Lichtenstein, Paul
- Abstract
Researchers have identified environmental risks that predict subsequent psychological and medical problems. Based on these correlational findings, researchers have developed and tested complex developmental models and have examined biological moderating factors (e.g., gene-environment interactions). In this context, we stress the critical need for researchers to use family-based, quasi-experimental designs when trying to integrate genetic and social science research involving environmental variables because these designs rigorously examine causal inferences by testing competing hypotheses. We argue that sibling comparison, offspring of twins or siblings, in vitro fertilization designs, and other genetically informed approaches play a unique role in bridging gaps between basic biological and social science research. We use studies on maternal smoking during pregnancy to exemplify these principles.
- Subjects
ECOLOGY; EXPERIMENTAL design; FAMILIES; GENES; GENETIC research; RESEARCH methodology; SMOKING; SOCIAL sciences; ENVIRONMENTAL exposure; PRENATAL exposure delayed effects
- Publication
American Journal of Public Health, 2013, Vol 103, Issue S1, pS46
- ISSN
0090-0036
- Publication type
Article
- DOI
10.2105/AJPH.2013.301252