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- Title
Possible Role of Noggin Gene in Mandibular Development.
- Authors
Gutiérrez Prieto, Sandra; Torres López, Diana; Gómez Rodríguez, Mariluz; García Robayo, Adriana
- Abstract
Background: Noggin (Nog) gene is one of the antagonists of bone morphogenic proteins (BMPs) and its function is to modulate the signs. When Nog's action is ineffective, an excessive activity of BMPs occur causing serious developmental abnormalities. Studies have shown that Nog is critical for chondrogenesis, osteogenesis, and joint training and appears to be involved in the growth of craniofacial structures, including the jaw. There are in the literature, few studies about the relationship between Nog and its role in the mandibular development. Purpose: This article reviews the molecular factors involved in the jaw development, focusing primarily on BMPs, their function, signaling pathway as Nog regulates this path. It leads to hypothesize the Nog's possible role on the mandibular development and how its alteration can cause mandibular micrognatism.
- Subjects
NOGGIN (Protein); CARRIER proteins; CHONDROGENESIS
- Publication
Universitas Odontológica, 2015, Vol 34, Issue 73, p8
- ISSN
0120-4319
- Publication type
Article