We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of comorbidities constituting the hematopoietic cell transplant (HCT)‐comorbidity index on the outcome of patients undergoing allogeneic HCT for acute myeloid leukemia.
- Authors
Khalil, Manar M. I.; Lipton, Jeffrey H.; Gupta, Vikas; Kim, Dennis D.; Kuruvilla, John; Viswabandya, Auro; Messner, Hans A.; Michelis, Fotios V.; Atenafu, Eshetu G.
- Abstract
Abstract: Objective: To investigate the prognostic impact of the individual component comorbidities of the hematopoietic cell transplant comorbidity index (HCT‐CI) in patients with acute myeloid leukemia (AML) that underwent allogeneic hematopoietic cell transplant (HCT). Method: This single‐center study retrospectively investigated the individual comorbidities of the HCT‐CI on the outcome of 418 patients that underwent HCT for AML, in CR1 (n = 303, 72%) or CR2 (n = 115, 28%) at our center between 1999 and 2014. Results: Median age at HCT was 50 years (range 18‐71). Univariate analysis of the HCT‐CI, grouped as score 0 (n = 109), 1‐2 (n = 157) and ≥3 (n = 152), demonstrated significant influence on overall survival (OS) (<italic>P</italic> = .004) and non‐relapse mortality (NRM) (<italic>P</italic> = .02). For individual comorbidities constituting the HCT‐CI, variables with a <italic>P</italic>‐value ≤ .2 on univariate analysis were included in the multivariable analysis. For OS, none of the comorbidities of the HCT‐CI demonstrated independent prognostic relevance. However, for NRM, multivariable analysis demonstrated pretransplant diabetes (HR = 2.17, 95% CI = 1.31‐3.60, <italic>P</italic> = .003) and cardiovascular comorbidity (HR = 1.78, 95% CI = 1.15‐2.76, <italic>P</italic> = .01) to be independent predictors of NRM post‐transplant. Conclusion: Among the comorbidities that compose the HCT‐CI, diabetes and cardiovascular comorbidity independently predict NRM in patients undergoing allogeneic HCT for AML. This information should be taken into consideration regarding post‐transplant monitoring and care.
- Subjects
ACUTE myeloid leukemia; HEMATOPOIETIC stem cell transplantation; COMORBIDITY; CARDIOVASCULAR diseases; HEALTH outcome assessment; PATIENTS
- Publication
European Journal of Haematology, 2018, Vol 100, Issue 2, p198
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13000