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- Title
Autoantibodies against Glutamate Receptor ε<sub>2</sub>-Subunit Detected in a Subgroup of Patients with Reversible Autoimmune Limbic Encephalitis.
- Authors
Kimura, A.; Sakurai, T.; Suzuki, Y.; Y.Hayashi; Hozumi, I.; Watanabe, O.; Arimura, K.; Takahashi, Y.; Inuzuka, T.
- Abstract
We investigated the presence of autoantibodies againstglutamate receptor (GluR) ε2 in serum and cerebrospinal fluid (CSF) samples from 12 consecutive patients with acute encephalitis/encephalopathy by immunoblotting using recombinant GluRε2 as antigen. In 4 patients, IgM autoantibodies against GluRε2 were detected in CSF in the early phase of the disease but were not detectable after several months. Seizures and psychiatric symptoms were noted during the acute phase of the disease in these 4 patients, who showed various degrees of residual amnesia. Immunotherapy was performed on 3 patients (patients 1, 3 and 4), and they showed marked improvements. Immunohistochemistry using these patients’ sera showed that immunoreactivity is specifically detected in the cytoplasm of rat hippocampal and cortical neurons. The clinical features and neuroimaging findings of patients with IgM autoantibodies against GluRε2 in CSF resemble those of patients with reversible autoimmune limbic encephalitis. Copyright © 2007 S. Karger AG, Basel
- Subjects
AUTOANTIBODIES; GLUTAMIC acid; AUTOIMMUNE diseases; ENCEPHALITIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY
- Publication
European Neurology, 2007, Vol 58, Issue 3, p152
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000104716