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- Title
Recent patent technologies of boswellic acids: A short review.
- Authors
Mehta, Meenu; Shukla, Bhavana; Khurana, Navneet; Arora, Prince; Sharma, Neha; Mahajan, Sanchit; Khatik, Gopal L.; Verma, Surajpal; Vyas, Manish; Satija, Saurabh
- Abstract
Boswellic acids (BAs) are pentacyclic triterpenoids and have potent biological properties that resulted in a number of protocols being developed for their synthesis. During the past 28 years (1990-2018), a number of synthetic BAs have been prepared. Both natural BAs and their synthetic derivatives can be used to treat various cancers as well as inflammatory diseases. This review covers patents on therapeutic activities of natural BAs and their synthetic derivatives published in past 28 years (1990-2018). BAs possess excellent anticancer and anti-inflammatory properties. A large number of BAs and their analogs have been prepared through modification at functional groups. Most importantly, the C-24 amide and amino derivatives demonstrated increased anticancer and anti-inflammatory activity compared with other BA derivatives. Furthermore, BAs have the potential to form conjugates with other anticancer drugs that will synergistically enhance their anticancer effects, and we believe that to get lead compounds, there needs to be a greater focus on the synthesis of halo derivatives of BAs.
- Subjects
PATENTS; TRITERPENOIDS; ALTERNATIVE treatment for cancer; ANTI-inflammatory agents; BACTERIAL conjugation
- Publication
Drug Invention Today, 2018, Vol 10, Issue 8, p1446
- ISSN
0975-7619
- Publication type
Article