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- Title
Fatal massive hepatic necrosis following acetaminophen overdose.
- Authors
McJunkin, B; Barwick, K W; Little, W C; Winfield, J B
- Abstract
A young woman ingested approximately 13 gm of an over-the-counter acetaminophen preparation and died seven days later in profound coma. Postmortem findings included massive centrilobular hepatic necrosis and renal tubular necrosis. Although hepatotoxicity secondary to acetaminophen overdose is well recognized in Britain, this entity has received little emphasis in the United States. Recognition of the potentially severe consequences is important because early treatment with sulfhydryl compounds may prevent serious liver injury.
- Publication
JAMA: Journal of the American Medical Association, 1976, Vol 236, p1874
- ISSN
0098-7484
- Publication type
journal article