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- Title
Prognostic role of early D-dimer level in patients with acute ischemic stroke.
- Authors
Zhang, Jing; Liu, Lin; Tao, Jie; Song, Yanlin; Fan, Yimeng; Gou, Maling; Xu, Jianguo
- Abstract
Object: The purpose of our study was to assess the prognostic role of early D-dimer level in patients with acute ischemic stroke (AIS). Methods: The included patients’ D-dimer levels have to be tested within 24 hours from stroke onset. Poor functional outcome was defined as modified Rankin Scale (mRS) ≥3. The endpoints included recurrence on 5-day diffusion-weighted imaging, 30-day mRS ≥3, 30-day mortality and 90-day mRS ≥3. Regarding to each endpoint, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the prognostic role of D-dimer in patients with AIS. Results: A total of 2,479 patients were included. The results showed that elevated D-dimer levels were associated with recurrence on 5-day diffusion-weighted imaging (OR = 2.28, 95% CI = 1.32–3.95), 30-day mRS≥3 (OR = 1.59, 95% CI = 1.37–1.85), 30-day mortality (OR = 1.92, 95% CI = 1.27–2.90) and 90-day mRS≥3 (OR = 1.61, 95% CI = 1.05–2.46). Conclusions: In conclusion, for patients with AIS, higher D-dimer level within 24 hours from stroke onset was associated with recurrence on 5-day diffusion-weighted imaging, mortality at 30 days, and poor functional outcome at both 30 days and 90 days. However, more studies are warranted to clarify this issue.
- Subjects
FIBRIN fragment D; STROKE treatment; DISEASE relapse; VASCULAR medicine; DIFFUSION magnetic resonance imaging
- Publication
PLoS ONE, 2019, Vol 14, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0211458