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- Title
The effects of hot air-dried white button mushroom powder on glycemic indices, lipid profile, inflammatory biomarkers and total antioxidant capacity in patients with type-2 diabetes mellitus: A randomized controlled trial.
- Authors
Yusefabad, Hadiseh Hashemi; Hosseini, Seyed Ahmad; Zakerkish, Mehrnoosh; Cheraghian, Bahman; Alipour, Meysam
- Abstract
Background: The inflammatory and metabolic responses to mushroom in type 2 diabetes mellitus (T2DM) are unknown. The study aimed to evaluate the effect of Hot Air-dried White Button Mushroom (HAD-WBM) powder on glycemic status, lipid profile, inflammatory markers, and total antioxidant capacity (TAC) in T2DM patients. Materials and Methods: This randomized controlled trial was conducted at Golestan Hospital, Ahvaz, Iran. Eligible patients were adults aged 20-50 with Type 2 diabetes. Patients were assigned to each group using a randomized block design with block randomization (n = 22, in each group). Randomization was performed by an assistant and group allocation was blinded for the investigator and participants. The intervention and control groups received 16 g/day HAD-WBM or cornstarch powder for 8 weeks. The primary outcomes of interest were fructosamine, fasting blood sugar (FBS), insulin, homeostatic model assessment for insulin resistance, and secondary outcomes were triglyceride, low-density lipoprotein (LDL), high-density lipoprotein, very-LDL, cholesterol, high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and TAC. Results: After 8 weeks, a significant decrease was observed in fructosamine (-0.228 ± 0.36 vs. 0.03 ± 0.38; P = 0.02) and LDL (-13.05 ± 20.67 vs. 0.81 ± 21.79; P = 0.04) in the HAD-WBM group compared to the control group. No significant changes were observed in fasting insulin and FBS between the two groups. However, a significant within-group reduction (-28.00 ± 42.46; P = 0.006) was observed for FBS in the HAD-WBM group. In the HAD-WBM group, insulin resistance reduced significantly at the end of the study (From 4.92 to 3.81; P = 0.016), but it was not significantly different between the two groups. There was no significant difference in TAC, hs-CRP, and IL-6 between the two groups. Conclusion: Considering the results of this study about the beneficial effects of HAD-WBM on the improvement of glycemic indices and LDL in T2DM patients, it is recommended that HAD-WBM could be used to control T2DM.
- Subjects
IRAN; BIOMARKERS; TRIGLYCERIDES; C-reactive protein; INTERLEUKINS; GLUCOSE intolerance; MUSHROOMS; INFLAMMATION; BLOOD sugar monitoring; ANTIOXIDANTS; LOW density lipoproteins; TYPE 2 diabetes; GLYCEMIC index; RANDOMIZED controlled trials; INSULIN; DIETARY supplements; STATISTICAL sampling; HIGH density lipoproteins; POWDERS; LIPIDS; INSULIN resistance
- Publication
Journal of Research in Medical Sciences, 2022, Vol 27, Issue 7, p1
- ISSN
1735-1995
- Publication type
Article
- DOI
10.4103/jrms.JRMS_513_20