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- Title
Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8-pentachlorodibenzofuran in rainbow trout.
- Authors
Muir, Derek C. G.; Yarechewski, Alvin L.; Metner, Donald A.; Lockhart, W. Lyle; Webster, G. R. Barrie; Friesen, Kenneth J.
- Abstract
Accumulation of and hepatic monooxygenase induction by 2,3,4,7,8-pentachlorodibenzofuran (PnCDF) were studied in juvenile rainbow trout ( Onchorhynchus mykiss) by feeding treated food for 31 d followed by a 180 d depuration period. Efficiency of assimilation was 44 and 41% at exposure concentrations of 9.0 and 0.82 ng g−1 PnCDF, respectively. Depuration of PnCDF followed first-order kinetics with half-lives (based on toluene extraction of 14C-radiolabel corrected for growth dilution) of 61 and 69 d at the low and high exposure concentrations, respectively. Monooxygenase enzyme induction measured by ethoxyresorufin- O-deethylase (EROD) activity in individual trout livers was 84- and four-fold higher after 31 d of exposure to 9.0 and 0.82 ng g−1, respectively, than in livers of unexposed fish. Sustained EROD activity at the high treatment concentrations was observed during the 180 d depuration phase. Ethoxyresorufin- O-deethylase activity declined at approximately half the rate of elimination of PnCDF. No significant differences between growth rates of treated and control fish were found.
- Publication
Environmental Toxicology & Chemistry, 1990, Vol 9, Issue 12, p1463
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1002/etc.5620091205