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- Title
The Role of Magnetoencephalography and Single-Photon Emission Computed Tomography in Evaluation of Children With Drug-Resistant Epilepsy.
- Authors
Edmonds, Benjamin D.; Welch, William; Sogawa, Yoshimi; Mountz, James; Bagić, Anto; Patterson, Christina
- Abstract
Surgery holds the best outcomes for drug-resistant epilepsy in children, making localization of a seizure focus essential. However, there is limited research on the contribution of magnetoencephalography and single-photon emission computed tomography (SPECT) to the presurgical evaluation of lesional and nonlesional pediatric patients. This study proposed to evaluate the concordance of SPECT and magnetoencephalography (MEG) to scalp electroencephalography (EEG) to determine their effective contribution to the presurgical evaluation. On review, MEG and SPECT studies for 28 drug-resistant epilepsy cases were completed at Children's Hospital of Pittsburgh from May 2012 to August 2018. Although not reaching statistical significance, MEG had increased lobar concordance with EEG compared with SPECT (68% vs 46%). MEG or SPECT results effectively provided localization data leading to 6 surgical evaluations and 3 resections with outcomes of Engel class I or II at 12 months. This study suggests MEG and SPECT provide valuable localizing information for presurgical epilepsy evaluation of children with drug-resistant epilepsy.
- Subjects
PITTSBURGH (Pa.); SINGLE-photon emission computed tomography; PEDIATRIC surgery; CHILDHOOD epilepsy; MAGNETOENCEPHALOGRAPHY; CHILDREN'S hospitals
- Publication
Journal of Child Neurology, 2021, Vol 36, Issue 8, p673
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073821996558