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- Title
Molecular epidemiology of an outbreak of hand, foot, and mouth disease associated with subgenotype C4a of enterovirus A71 in Nanchang, China in 2014.
- Authors
Zhou, Xianfeng; Zhu, Qingxiong; Xia, Wen; He, Fenglan; Hu, Maohong; Ni, Xiansheng; Gao, Meiling; Chen, Haiying; Chen, Shengen
- Abstract
An outbreak of hand, foot, and mouth disease was reported through hospital-based surveillance in Nanchang, China in 2014. A total of 244 cases were reported, 176 (72.1%) cases were tested positive for enteroviruses by direct reverse transcription-polymerase chain reaction, in which enterovirus A71 (EV-A71), coxsackievirus A16 (CV-A16), and untyped enteroviruses (UEV) accounted for 84.1%, 3.4%, and 12.5%, respectively. In this outbreak, children under 5 years old constituted more than 98% of the positive cases, and the ratio of male to female cases was 2.6 to 1 ( P < 0.01). Phylogenetic analysis indicated that the Nanchang EV-A71 strains belonged to subgenotype C4a undergoing continuously evolutionary changes. J. Med. Virol. 87:2154-2158, 2015. © 2015 Wiley Periodicals, Inc.
- Publication
Journal of Medical Virology, 2015, Vol 87, Issue 12, p2154
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.24288