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- Title
Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19–Depleted Stem Cell Transplantation.
- Authors
Gössling, Katharina L; Fouz, Hiba; Kyrillopoulou, Olga; Aubin, Matthias; Maecker-Kolhoff, Britta; Adams, Ortwin; Borkhardt, Arndt; Babor, Florian; Schuster, Friedhelm R; Siepermann, Meinolf; Schumm, Michael; Lang, Peter; Eiz-Vesper, Britta; Meisel, Roland
- Abstract
Here, we report the case of severe adenoviremia in a 7-year-old boy with highly-resistant, acute leukemia. A combined approach of αβTCR-CD19–depleted stem cell transplantation, enabling immunosuppression-free post-transplant care, and early transfer of adenovirus-specific donor T cells during aplasia resulted in rapid and complete clearance of the treatment-refractory adenoviremia.
- Subjects
LYMPHOBLASTIC leukemia treatment; T cells; DNA virus diseases; HEMATOPOIETIC stem cell transplantation; IMMUNOSUPPRESSION; HLA-B27 antigen; DISEASE remission; THERAPEUTICS; TRANSPLANTATION of organs, tissues, etc.
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 8, p1406
- ISSN
1058-4838
- Publication type
Case Study
- DOI
10.1093/cid/ciy820