We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
microRNAs deregulation in head and neck squamous cell carcinoma.
- Authors
Carron, Juliana; Torricelli, Caroline; Silva, Janet K.; Queiroz, Gabriela S. R.; Ortega, Manoela M.; Lima, Carmen S. P.; Lourenço, Gustavo J.
- Abstract
Head and neck (HN) squamous cell carcinoma (SCC) is the eighth most common human cancer worldwide. Besides tobacco and alcohol consumption, genetic and epigenetic alterations play an important role in HNSCC occurrence and progression. microRNAs (miRNAs) are small noncoding RNAs that regulate cell cycle, proliferation, development, differentiation, and apoptosis by interfering in gene expression. Expression profiling of miRNAs showed that some miRNAs are upregulated or downregulated in tumor cells when compared with the normal cells. The present review focuses on the role of miRNAs deregulations in HNSCC, enrolled in risk, development, outcome, and therapy sensitivity. Moreover, the influence of single nucleotide variants in miRNAs target sites, miRNAs seed sites, and miRNAs‐processing genes in HNSCC was also revised. Due to its potential for cancer diagnosis, progression, and as a therapeutic target, miRNAs may bring new perspectives in HNSCC understanding and therapy, especially for those patients with no or insufficient treatment options.
- Subjects
SQUAMOUS cell carcinoma; MICRORNA; NON-coding RNA; ALCOHOL drinking; GENETIC regulation
- Publication
Head & Neck, 2021, Vol 43, Issue 2, p645
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26533