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- Title
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta‐analysis.
- Authors
Faisal, Muhammad; Seemann, Rudolf; Lill, Claudia; Hamzavi, Sasan; Wutzl, Arno; Erovic, Boban M.; Janik, Stefan
- Abstract
Sinonasal undifferentiated carcinomas (SNUCs), being an aggressive malignancy with dismal survival outcome, have given limited consideration regarding management of regional failures. A total of 12 studies, published between 1999 and 2019, met inclusion criteria. We performed a meta‐analysis assessing regional (neck) relapse after elective neck treatment compared to observation in clinically node negative (N0) necks. Clinical data of 255 patients were used for meta‐analysis. Among them, 83.4% of patients presented with T4 tumors and 14.1% had positive neck nodes. Elective neck treatment was applied in 49.5% of analyzed patients. Regional relapses occurred in 3.7% of patients who have undergone elective neck treatment compared to 26.4% in patients who had not. Elective neck treatment significantly reduced the risk of regional recurrence (odds ratio 0.20; 95% confidence interval 0.08‐0.49; P =.0004). The meta‐analysis indicates that elective neck treatment could significantly reduce the risk of regional failures in patients with SNUCs.
- Subjects
CARCINOMA; META-analysis; NECK; ODDS ratio; CONFIDENCE intervals
- Publication
Head & Neck, 2020, Vol 42, Issue 5, p1057
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26077