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- Title
Effect of surgical intervention on circulating tumor cells in patients with squamous cell carcinoma of the head and neck using a negative enrichment technology.
- Authors
Jatana, Kris R.; Balasubramanian, Priya; McMullen, Kyle P.; Lang, Jas C.; Teknos, Theodoros N.; Chalmers, Jeffrey J.
- Abstract
ABSTRACT Background The purpose of this study was to investigate the impact of surgical intervention on detection of circulating tumor cells (CTCs) in patients with squamous cell carcinoma of the head and neck (SCCHN.) Methods We utilized a negative depletion technique to identify cytokeratin (CK)-positive CTCs. The numbers of CTCs immediately before and after surgical resection were compared. Results Seventy-six blood samples from 38 patients with SCCHN were examined. Seventy-nine percent of the patients had CTCs detected before and after surgery. A total of 7.89% had no CTCs before surgery, yet had CTCs identified after surgery. Overall, 60.5% of patients had an increased number of CTCs/mL after surgery with a mean increase of 6.63-fold. A statistically significant increase in CTCs was seen after surgery ( p = .02). Conclusion The timing of sample collection in patients with SCCHN who have surgical intervention can potentially impact the number of CTCs identified. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1799-1803, 2016
- Subjects
CIRCULATING tumor DNA; SQUAMOUS cell carcinoma; HEAD &; neck cancer; HEAD diseases; CARCINOMA
- Publication
Head & Neck, 2016, Vol 38, Issue 12, p1799
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24519