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- Title
Alendronate Treatment of the Brtl Osteogenesis Imperfecta Mouse Improves Femoral Geometry and Load Response Before Fracture but Decreases Predicted Material Properties and Has Detrimental Effects on Osteoblasts and Bone Formation.
- Authors
Uveges, Thomas E.; Kozloff, Kenneth M.; Ty, Jennifer M.; Ledgard, Felicia; Raggio, Cathleen L.; Gronowicz, Gloria; Goldstein, Steven A.; Marini, Joan C.
- Abstract
The article presents a study in which Brtl and wildtype mice were treated with alendronate (Aln) for six or 12 weeks and compared femora from both genotypes that were treated and untreated. The similarity in the response of the bone to Aln treatment in both the Brtl and wildtype mice is described, noting that Brtl mice are effective models for the effects of bisphosphonate in classical osteogenesis imperfecta (OI).
- Subjects
DIPHOSPHONATES; PHARMACEUTICAL research; LABORATORY mice; OSTEOGENESIS imperfecta
- Publication
Journal of Bone & Mineral Research, 2009, Vol 24, Issue 5, p849
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/jbmr.081238