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- Title
Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury.
- Authors
CAN, M.; GUL, S.; BEKTAS, S.; HANCI, V.; ACIKGOZ, S.
- Abstract
Background: The aim of this study was to compare the anti-inflammatory response of methylprednisolone and the α2-agonist dexmedetomidine in spinal cord injury (SCI). Methods: Twenty-four male adult Wistar albino rats, weight 200–250 g, were included in the study. The rats were divided into four groups as follows: the control group ( n: 6) received only laminectomy; the SCI group ( n: 6) with trauma alone; the SCI+methylprednisolone group ( n: 6) with trauma and 30 mg/kg methylprednisolone, followed by a maintenance dose of 5.4 mg/kg/h; and the SCI+dexmedetomidine group ( n: 6) with trauma and 10 μg/kg dexmedetomidine treatment intraperitoneally. Twenty-four hours after the trauma, spinal cord samples were taken for histopathological examination and serum samples were collected for interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α measurement. Results: TNF-α ( P=0.009) and IL-6 ( P=0.009) levels were significantly increased in the SCI group. TNF-α and IL-6 levels were significantly decreased with methylprednisolone ( P=0.002, 0.002) and dexmedetomidine ( P=0.002, 0.009) treatment, respectively. Methylprednisolone and dexmedetomidine treatment reduced neutrophils' infiltration in SCI. Conclusions: The current study does not clarify the definitive mechanism by which dexmedetomidine decreases inflammatory cytokines but it is the first study to report the anti-inflammatory effect of dexmedetomidine in SCI. Further studies are required to elucidate the effects of dexmedetomidine on the inflammatory response.
- Subjects
SPINAL cord injuries; INFLAMMATION; LABORATORY rats; ALBINOS &; albinism; INTERLEUKIN-6
- Publication
Acta Anaesthesiologica Scandinavica, 2009, Vol 53, Issue 8, p1068
- ISSN
0001-5172
- Publication type
Article
- DOI
10.1111/j.1399-6576.2009.02019.x