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- Title
Far-Infrared Therapy Based on Graphene Ameliorates High-Fat Diet-Induced Anxiety-Like Behavior in Obese Mice via Alleviating Intestinal Barrier Damage and Neuroinflammation.
- Authors
Zhang, Jin-shui; Li, Shuo; Cheng, Xin; Tan, Xiao-cui; Huang, Yu-long; Dong, Hua-jin; Xue, Rui; Zhang, Yang; Li, Jing-cao; Feng, Xiao-xing; Deng, Yun; Zhang, You-zhi
- Abstract
The consumption of a high-fat diet (HFD) has been implicated in the etiology of obesity and various neuropsychiatric disturbances, including anxiety and depression. Compelling evidence suggests that far-infrared ray (FIR) possesses beneficial effects on emotional disorders. However, the efficacy of FIR therapy in addressing HFD-induced anxiety and the underlying mechanisms remain to be elucidated. Here, we postulate that FIR emitted from a graphene-based therapeutic device may mitigate HFD-induced anxiety behaviors. The graphene-FIR modify the gut microbiota in HFD-mice, particularly by an enriched abundance of beneficial bacteria Clostridiaceae and Erysipelotrichaceae, coupled with a diminution of harmful bacteria Lachnospiraceae, Anaerovoracaceae, Holdemania and Marvinbryantia. Graphene-FIR also improved intestinal barrier function, as evidenced by the augmented expression of the tight junction protein occludin and G protein-coupled receptor 43 (GPR43). In serum level, we observed the decreased free fatty acids (FFA), lipopolysaccharides (LPS), diamine oxidase (DAO) and D-lactate, and increased the glucagon-like peptide-2 (GLP-2) levels in graphene-FIR mice. Simultaneously, inflammatory cytokines IL-6, IL-1β, and TNF-α manifested a decrease subsequent to graphene-FIR treatment in both peripheral and central system. Notably, graphene-FIR inhibited over expression of astrocytes and microglia. We further noticed that the elevated the BDNF and decreased TLR4 and NF-κB expression in graphene-FIR group. Overall, our study reveals that graphene-FIR rescued HFD-induced anxiety via improving the intestine permeability and the integrity of blood–brain barrier, and reduced inflammatory response by down regulating TLR4/NF-κB inflammatory pathway.
- Subjects
OCCLUDINS; INTESTINAL barrier function; G protein coupled receptors; FREE fatty acids; TIGHT junctions; ANXIETY
- Publication
Neurochemical Research, 2024, Vol 49, Issue 7, p1735
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-024-04133-9