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- Title
Synthesis of ring opening of evodiamine derivatives and evaluation on their biological activity.
- Authors
Guo, Weihang; Wang, Xianheng; Zhang, Jidong; Zhang, Tingting; Lv, Hongfeng; Zhao, Changkuo
- Abstract
As a main bioactive component extracted from Evodiae fructus, evodiamine has a variety of pharmacological activities. In this paper, evodiamine was chosen as starting material to react with different halides. Upon treatment of TFA, a series of novel ring‐opening evodiamine derivatives 3a–o were successfully synthesized in a moderate to high yields. These obtained compounds exhibit a moderate to good antitumor activity against BGC803 and SW480 in vitro test by MTT assay. The results showed that hexyl substituted evodiamine derivative (3j, R=hexyl) has a strong antitumor activity against BGC803 and SW480.
- Subjects
ANTINEOPLASTIC agents; BIOACTIVE compounds
- Publication
Chemical Biology & Drug Design, 2022, Vol 99, Issue 4, p535
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.13996