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- Title
Synthesis and evaluation of anti-inflammatory properties of silver nanoparticle suspensions in experimental colitis in mice.
- Authors
Siczek, Krzysztof; Zatorski, Hubert; Chmielowiec ‐ Korzeniowska, Anna; Pulit ‐ Prociak, Jolanta; Śmiech, Magdalena; Kordek, Radzisław; Tymczyna, Leszek; Banach, Marcin; Fichna, Jakub
- Abstract
The aim of our study was to investigate the effect of newly developed silver nanoparticle aqueous suspensions NanoAg1 and NanoAg2 in the mouse models mimicking ulcerative colitis and Crohn's disease. NanoAg1 and NanoAg2 were synthesized in aqueous medium with the involvement of tannic acid. To elucidate their anti-inflammatory activity, semi-chronic mouse models of inflammation induced by dextrane sulfate sodium addition to drinking water and intracolonic (i.c.) administration of 2,4,6-trinitrobenzenesulfonic acid were used. NanoAg1 and NanoAg2 (500 mg/dm3, 100 μl/animal, i.c., once daily) significantly ameliorated colitis in dextrane sulfate sodium- and 2,4,6-trinitrobenzenesulfonic acid-induced mouse models of colonic inflammation, as indicated by reduced macroscopic, ulcer and microscopic scores. The anti-inflammatory effect was dependent on the shape and diameter of silver nanoparticles, as indicated by weaker effect of NanoAg1 than NanoAg2. In addition, administration of NanoAg2, but not NanoAg1, modulated colonic microbiota, as indicated by reduced number of Escherichia coli and Clostridium perfringens, and increased number of Lactobacillus sp. Summarizing, NanoAg1 and NanoAg2 after administered i.c. effectively alleviate colitis in experimental models of ulcerative colitis and Crohn's disease in mice. Therefore, NanoAg1 and NanoAg2 administered i.c. have the potential to become valuable agents for the treatment of inflammatory bowel diseases.
- Subjects
INFLAMMATORY bowel disease treatment; ULCERATIVE colitis; COLITIS treatment; SILVER nanoparticles; NANOSTRUCTURED materials synthesis; ANTI-inflammatory agents; LABORATORY mice
- Publication
Chemical Biology & Drug Design, 2017, Vol 89, Issue 4, p538
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.12876