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- Title
A Note on Derivatives of Isoniazid, Rifampicin, and Pyrazinamide Showing Activity Against Resistant Mycobacterium tuberculosis.
- Authors
Nusrath Unissa, Ameeruddin; Hanna, Luke Elizabeth; Swaminathan, Soumya
- Abstract
Drug-resistant tuberculosis ( DR- TB) is a serious problem that impedes the success of the TB control program. Of note, multidrug-resistant ( MDR)- TB and extensively drug-resistant ( XDR)- TB have certainly complicated the scenario. One of the possible strategies to overcome drug resistance in an economic and simple manner would involve modification of existing anti- TB drugs to obtain derivatives that can work on resistant TB bacilli. These may have improved half-life and increased bioavailability, be more efficacious, and serve as cost-effective alternatives, as compared to new drugs identified through conventional methods of drug discovery and development. Although extensive literature is available on the activity of various derivatives of first-line drugs (isoniazid, rifampicin and pyrazinamide) on drug-susceptible Mycobacterium tuberculosis ( MTB), reports on the activity of derivatives on resistant MTB are very limited, to our knowledge. In light of this, the present review aims to provide a concise report on the derivatives of first-line drugs that have the potential to overcome the resistance to the parental drug and could thus serve as effective alternatives.
- Subjects
MYCOBACTERIUM tuberculosis; MULTIDRUG resistance in bacteria; ISONIAZID; RIFAMPIN; PYRAZINAMIDE; BIOAVAILABILITY; THERAPEUTICS
- Publication
Chemical Biology & Drug Design, 2016, Vol 87, Issue 4, p537
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.12684