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- Title
The TGF-β Pathway as an Emerging Target for Chagas Disease Therapy.
- Authors
Araújo-Jorge, T C; Waghabi, M C; Bailly, S; Feige, J-J
- Abstract
Transforming growth factor-β (TGF-β) influences the development of myocardiopathy in Chagas disease through regulation of (i) parasite invasion of heart cells, (ii) an intracellular parasite cycle, (iii) inflammation and immune response, (iv) heart fibrosis and remodeling, and (v) gap junction modulation and heart conduction. In this review, we discuss the rationale for developing TGF-β signaling-interfering therapies as adjuvant approaches for the management of the cardiac alterations of Chagas disease-affected patients.
- Subjects
TRANSFORMING growth factors; CHAGAS' disease treatment; TARGETED drug delivery; CARDIOMYOPATHIES; HEART cells; HEART fibrosis; IMMUNE response
- Publication
Clinical Pharmacology & Therapeutics, 2012, Vol 92, Issue 5, p613
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2012.102