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- Title
95: Prognostic Factors in Renal Cell Carcinoma in Taiwan population.
- Authors
See-Tong Pang; Ying-Hsu Chang; Cheng-Keng Chuang; Chun-Te Wu; Kun-Lung Chuang; Shuen-Kuei Liao
- Abstract
Introduction: We assessed the value of TNM staging for predicting outcome of renal cell carcinoma (RCC) in Taiwan. Methods: To analyze 298 RCC patients who were surgically treated at this hospital between 1998 and 2003, tumor staging was performed according to the 2002 American Joint Committee on Cancer (AJCC) TNM classification. The Fuhrman grading system was used for nuclear grading of tumors. The 5-year cancer-specific survival data were analyzed by Kaplan-Meier statistical analysis. Prognostic factors were calculated with Log Rank test and Cox proportional hazards regression method. Results: The mean follow-up period of these patients was 40.6 months. The 5-year cancer-specific survival rates were 85.6%, 69.2%, 50.0% and 26.0% in T1, T2, T3 and T4, respectively. The survival rates were 87.2%, 73.6%, 47.5% and 40.5% in TNM stages 1, II, III and IV, respectively. In tumor grades 1-4, the survival rates were 77.1%, 77.5%, 48.9% and 28.6%, respectively. The survival rates for patients with and without tumor necrosis were 68.3% and 74.6%, respectively. The survival rate was 72.5% for patients with clear cell type, 69.9% for papillary type, 85.9% for chromophobe type and 67.7% for sarcomatoid type. Univariate analysis revealed that tumor grade, TNM stage and tumor stage were statistically significant prognostic factors. Multivariate analysis showed that TNM stage was the most important predictive factor in patient survival. Conclusions: In this population-based study, TNM stage provides the most important prognostic factor of RCC in the population of Taiwan.
- Subjects
TAIWAN; RENAL cell carcinoma; CANCER patients; TUMOR classification; TUMOR necrosis factors
- Publication
Indian Journal of Urology, 2008, Vol 24, pS83
- ISSN
0970-1591
- Publication type
Article