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- Title
Insulin Sensitivity, Insulin Secretion, and Abdominal Fat.
- Authors
Wagenknecht, Lynne E.; Langefeld, Carl D.; Scherzinger, Ann L.; Norris, Jill M.; Haffner, Steven M.; Saad, Mohammed F.; Bergman, Richard N.
- Abstract
The relationship between insulin sensitivity and overall obesity is well established. However, there remains debate as to which of the fat depots, visceral abdominal tissue (VAT) or subcutaneous abdominal tissue (SAT), is of greater importance. Also, the relationship between fat distribution and insulin secretion is largely unknown. We studied S[sub I], acute insulin response (AIR), and disposition index (DI), as obtained by minimal model analysis, in 999 Hispanic and 458 African-American men and women as part of the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. VAT and SAT were measured from computed tomography scans performed at the L4/L5 vertebral region. A mixed-model approach was used to determine the relationship between each of the glucose homeostasis measures (SI[sub ,] AIR, and DI) versus abdominal fat measures. Mean values were as follows: age, 41 years; S[sub I], 1.98 10[sup -4] · min[sup -1] · µU[sup -1] · ml[sup -1]; AIR, 840 pmol · ml[sup -1] · min[sup -1]; BMI, 28.5 kg/m²; VAT, 100 cm²; and SAT, 333 cm². SAT, VAT, and their joint interaction were each inversely and significantly associated with S[sub I], adjusting for age, sex, ethnicity, and BMI. SAT, but not VAT, was positively associated with AIR, except when additionally adjusting for S[sub I], in which case VAT was inversely associated with AIR. VAT and the joint interaction of VAT and SAT were inversely associated with DI. The fat measures explained 27% of the model R² for S[sub I], 16% for AIR, and 16% for DI. Thus, fat distribution is an important determinant of both insulin resistance and insulin secretion.
- Subjects
INSULIN; OBESITY; ATHEROSCLEROSIS
- Publication
Diabetes, 2003, Vol 52, Issue 10, p2490
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.52.10.2490