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- Title
While Tinkering With the β-Cell...Metabolic Regulatory Mechanisms and New Therapeutic Strategies.
- Authors
Newgard, Christopher B.
- Abstract
A common feature of the two major forms of human diabetes is the partial or complete loss of insulin secretion from β-cells in the pancreatic islets of Langerhans. In this article, we review the development of a set of tools for studying β-cell biology and their application to understanding of fuel-mediated insulin secretion and enhancement of β-cell survival. Insights into these basic issues are likely to be useful for the design of new drug and cell-based diabetes therapies.
- Subjects
PANCREATIC beta cells; INSULIN; DIABETES
- Publication
Diabetes, 2002, Vol 51, Issue 11, p3141
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.51.11.3141