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- Title
Correction of erythrocyte deformability defect in ALX-induced diabetic rabbits after treatment with aminoguanidine.
- Authors
Brown, Clinton D.; Zhao, Zhong H.; De Alvaro, Fernando; Seewai Chan; Friedman, Eli A.; Brown, C D; Zhao, Z H; De Alvaro, F; Chan, S; Friedman, E A
- Abstract
To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and after 20 wk of treatment with aminoguanidine (100 mg.kg-1 x day-1). The key findings were as follows: 1) at 12 wk of treatment with aminoguanidine, mean erythrocyte deformability normalized and remained within the normal reference range throughout the period of aminoguanidine administration; 2) 10 wk after discontinuing aminoguanidine in a subset of diabetic rabbits, mean erythrocyte deformability deteriorated by approximately 50%; 3) blood glucose and total GHb did not vary significantly during treatment with aminoguanidine nor after its discontinuation.
- Publication
Diabetes, 1993, Vol 42, Issue 4, p590
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.42.4.590