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- Title
CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone.
- Authors
Bradley, Brenda J.; Haskins, Kathryn; La Rosa, Francisco G.; Lafferty, Kevin J.; Bradley, B J; Haskins, K; La Rosa, F G; Lafferty, K J
- Abstract
A panel of CD4+ T-cell clones has been isolated from the spleen and lymph nodes of diabetic NOD mice. These clones have been shown to be islet-specific both in vivo and in vitro. One of the clones, BDC-6.9, initiates extensive damage to islet tissue when placed adjacent to an NOD islet graft that has been used to reverse diabetes in (CBA x NOD)F1 recipients or when injected intraperitoneally into such animals. In this study, we show that BDC-6.9 T cells can initiate islet destruction in the absence of detectable CD8 T cells either in the periphery or in the lesion that develops after the transfer of the cloned islet-reactive T cells.
- Publication
Diabetes, 1992, Vol 41, Issue 12, p1603
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.41.12.1603