We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E rats.
- Authors
Elias, Dana; Bone, Adrian J.; Baird, Joyce D.; Cooke, Anne; Cohen, Irun R.; Elias, D; Bone, A J; Baird, J D; Cooke, A; Cohen, I R
- Abstract
BB/E rats spontaneously develop a form of autoimmune diabetes resembling insulin-dependent diabetes mellitus (IDDM) in humans. IDDM results from central destruction of the insulin-producing beta-cells of the pancreatic islets. Herein, we report that the outbreak of IDDM in BB/E rats is preceded by the spontaneous development of an anti-idiotypic antibody to a particular antibody to insulin made by the rats. This anti-idiotype, designated anti-DM-id, behaves as an antibody to the insulin-hormone receptor. Thus, a spontaneous anti-idiotypic antibody network whose products can affect the peripheral utilization of insulin seems to accompany the central destruction of beta-cells in developing IDDM.
- Publication
Diabetes, 1990, Vol 39, Issue 12, p1467
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.39.12.1467