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- Title
To Bet or Not to Bet on T-bet As a Therapeutic Target in Emphysema?
- Authors
Xiaoyun Wang; Rojas-Quintero, Joselyn; Owen, Caroline A.
- Abstract
The article report that when challenged with porcine pancreatic elastase (PPE) delivered by the intratracheal route, T-bet2/2 mice developed exaggerated emphysema compared with wild-type (WT) mice. It mentions that exaggerated emphysema phenotype in the PPE-treated T-bet2/2 mice was associated with enhanced early recruitment of neutrophils and lymphocytes into their lungs.
- Subjects
PANCREATIC elastase; PULMONARY emphysema; MICE; PHENOTYPES; NEUTROPHILS
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2019, Vol 61, Issue 4, p414
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2019-0118ed