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- Title
The Relationship Between Gene Mutations and the Clinicopathological Features and Prognosis of Gastric Cancer.
- Authors
Nie, Zunzhen; Zeng, Kaixuan; Yan, Qingguo; Liu, Yuangang; Bian, Yawei; Zhu, Jin; Guo, Zhenzhen; He, Furong; Shi, Hai; Guo, Ying
- Abstract
Current treatments for gastric cancer (GC) are suboptimal. Potential therapeutic targets for GC were screened using next-generation sequencing. We examined many mutation genes linked to GC, including TP53 (60%), PIK3CA (19%), LRP1B (13%), and ERBB2 (12%), ARID1A (9%), KMT2C (9%), and KRAS (7%). The KMT2C, KRAS, CDK6, and ARID1A wild-type genes were dominant in diffuse-type GC (P <.05), but mutations did not influence prognosis. Patients with APC (6%) and CDH1 (8%) wild-type GC presented with vascular invasion (P <.05). Patients with ATR (2%) wild-type GC were prone to lymph node metastasis (P <.05). Patients with ARID1A (9%) wild-type GC had reduced programmed death ligand 1 expression (<1, P <.05). We found that patients who received chemotherapy had a better prognosis than those who did not (although there was no statistical difference), with platinum-based group having better prognosis and uracil combined with paclitaxel group having worse prognosis.
- Subjects
STOMACH cancer; GENETIC mutation; CANCER prognosis; LYMPHATIC metastasis; NUCLEOTIDE sequencing; PROGRESSION-free survival
- Publication
International Journal of Surgical Pathology, 2024, Vol 32, Issue 3, p486
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969231188421