We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reply to Kawasaki et al Regarding "Nuclear Insulinoma-Associated Protein 1 Expression as a Marker of Neuroendocrine Differentiation in Neoplasms of the Breast".
- Authors
Van Bockstal, Mieke R.; Galant, Christine
- Abstract
Our first cohort comprised 22 breast tumors with varying degrees of neuroendocrine differentiation, including three invasive carcinomas of no special type (NST) with variable levels of neuroendocrine biomarker expression (ie INSM1, synaptophysin and chromogranin A). Keywords: breast; insulinoma-associated protein 1; neuroendocrine differentiation; chromogranin A; synaptophysin EN breast insulinoma-associated protein 1 neuroendocrine differentiation chromogranin A synaptophysin 472 475 4 05/18/22 20220601 NES 220601 Previously we studied the expression of insulinoma-associated protein 1 (INSM1) in two series of breast tumors, thereby demonstrating that INSM1 immunohistochemistry is a useful addition to traditional biomarkers for neuroendocrine differentiation, such as chromogranin A and synaptophysin.[1] INSM1 is a nuclear marker, which is often easier to interpret than cytoplasmic proteins. We did not observe any breast tumors with diffuse strong INSM1 expression in the absence of traditional neuroendocrine biomarker expression.
- Subjects
BREAST tumors; NUCLEAR proteins; NEUROENDOCRINE tumors; BREAST; PROTEIN expression; PROGNOSIS
- Publication
International Journal of Surgical Pathology, 2022, Vol 30, Issue 4, p472
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969211070173