We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of smoking habit on adult-onset Still's disease prognosis, findings from a multicentre observational study.
- Authors
Ruscitti, Piero; Di Cola, Ilenia; Berardicurti, Onorina; Conforti, Alessandro; Iacono, Daniela; Pantano, Ilenia; Rozza, Gelsomina; Rossi, Silvia; De Ludovico, Stefano; Balduzzi, Silvia; Vitale, Antonio; Caso, Francesco; Costa, Luisa; Prete, Marcella; Navarini, Luca; Atzeni, Fabiola; Guggino, Giuliana; Perosa, Federico; Cantarini, Luca; Frediani, Bruno
- Abstract
The objective of this study is to describe the possible prognostic impact of smoking habit on adult-onset Still's disease (AOSD) patients, by the assessment of clinical characteristics, life-threatening complications occurrence, and mortality in smokers than non-smokers. A multicentre retrospective study of prospectively followed-up AOSD patients included in Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort was conducted. Out of 185 AOSD assessed patients, 45 smokers were identified. These showed a higher frequency of pericarditis (35.5% vs 16.4%, p = 0.011), pleuritis (33.3% vs 14.3%, p = 0.008), and abdominal pain (17.7% vs 6.4%, p = 0.035). Furthermore, smokers showed higher values of systemic score (6.4 ± 2.2 vs 5.4 ± 1.8, p = 0.004), an increased rate of macrophage activation syndrome (MAS) (28.9% vs 6.4%, p < 0.0001) and of parenchymal lung disease (17.7% vs 12.6%, p = 0.035). Although not significant, these patients more frequently experienced a poor prognosis (13.3% vs 4.3%, p = 0.074). Smoking habit predicted MAS occurrence in both univariate (HR: 5.98, 95% CI: 2.45–14.57, p < 0.0001) and multivariate regression models (HR: 6.21, 95% CI: 2.46–15.70, p < 0.0001). Smokers had a significant higher risk of parenchymal lung disease in both univariate (HR: 3.97, 95% CI: 1.43–11.02, p = 0.008) and multivariate regression models (HR: 3.90, 95% CI: 1.36–11.23, p = 0.012). Smoking habit also increased the risk of mortality in univariate regression model (HR: 4.25, 95% CI: 1.33–13.55, p = 0.015). Smoking habit resulted to be a negative prognostic factor on AOSD patients. Smokers were characterised by a higher frequency of serositis and higher values of systemic score. Additionally, these patients were more frequently burdened by MAS and parenchymal lung disease associated with a poor prognosis. Key points • Smoking habit resulted to be a negative prognostic factor on AOSD. • Smokers were characterised by an increased frequency of serositis and higher values of systemic score. • Cigarette exposure was associated with MAS and parenchymal lung disease in AOSD.
- Subjects
STILL'S disease; SMOKING; PROGNOSIS; LUNG diseases; MACROPHAGE activation syndrome; INTERSTITIAL lung diseases
- Publication
Clinical Rheumatology, 2022, Vol 41, Issue 3, p641
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-021-05929-8