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- Title
Acute generalized exanthematous pustulosis and toxic epidermal necrolysis induced by hydroxychloroquine.
- Authors
Lateef, Aisha; Kong-Bing Tan; Tang Ching Lau
- Abstract
Acute generalized exanthematous pustulosis (AGEP) and toxic epidermal necrolysis (TEN) are both severe cutaneous adverse reactions, mostly to drugs. Although predominantly involving skin, they differ significantly in presentations, prognosis, pathology, immunogenesis, and treatment. They have very rarely been described to occur simultaneously in a patient, manifesting as AGEP–TEN overlap. We describe a 67-year-old Chinese lady with systemic lupus erythematosus who presented with features of AGEP but evolved to AGEP–TEN overlap as an adverse reaction to hydroxychloroquine (HCQ) treatment. This case is the first reported case of AGEP–TEN overlap secondary to HCQ and highlights the need for constant surveillance for rare adverse events that may manifest even after decades of use of the drug worldwide.
- Subjects
CHLOROQUINE; DRUG side effects; SKIN diseases; AUTOIMMUNE diseases; PREVENTIVE medicine
- Publication
Clinical Rheumatology, 2009, Vol 28, Issue 12, p1449
- ISSN
0770-3198
- Publication type
Report
- DOI
10.1007/s10067-009-1262-4