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- Title
Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction.
- Authors
Samnegård A; Silveira A; Lundman P; Boquist S; Odeberg J; Hulthe J; McPheat W; Tornvall P; Bergstrand L; Ericsson C; Hamsten A; Eriksson P; Samnegård, A; Silveira, A; Lundman, P; Boquist, S; Odeberg, J; Hulthe, J; McPheat, W; Tornvall, P
- Abstract
<bold>Objectives: </bold>Matrix metalloproteinase-3 (MMP-3) is implicated in the formation of atherosclerotic plaques, and the MMP-3 -1612 5A/6A polymorphism is associated with myocardial infarction (MI) and stable coronary artery disease (CAD). The present study examined whether the -1612 5A/6A polymorphism in the promoter region of the MMP-3 gene influences serum concentrations of MMP-3 and whether serum concentrations of MMP-3 are related to extent of coronary atherosclerosis and risk of MI. <bold>Design and Subjects: </bold>This case-control study was conducted in three hospitals in the northern part of Stockholm. A total of 755 MI patients aged below 60 were screened, 433 entered and 387 completed the study. Three hundred and eighty-seven sex- and age-matched control subjects were recruited from the general population of the same county. <bold>Methods: </bold>The MMP-3 genotype was determined by Pyrosequencing(TM) and the serum MMP-3 concentration was quantified with an immunoassay. Severity and extension of CAD was assessed by quantitative coronary angiography in a subgroup of patients (n=243). <bold>Results: </bold>Patients had lower serum MMP-3 concentration than controls. There was a strong association between MMP-3 -1612 5A/6A genotype and serum concentrations of MMP-3. The presence of one or two copies of the 6A-allele was associated with a graded increase in serum MMP-3. In female patients there was an inverse correlation (r=-0.39, P<0.05) between serum MMP-3 concentration and plaque area. Conclusion. In conclusion, the serum concentration of MMP-3 is influenced by MMP-3 -1612 5A/6A genotype and associated with MI.
- Publication
Journal of Internal Medicine, 2005, Vol 258, Issue 5, p411
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1111/j.1365-2796.2005.01561.x