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- Title
The spectrum of 5-fluorouracil cardiotoxicity.
- Authors
McLachlan, Sue‐Anne; Millward, Michael J; Toner, Guy C; Guiney, Michael J; Bishop, James F; McLachlan, S A; Millward, M J; Toner, G C; Guiney, M J; Bishop, J F
- Abstract
<bold>Objective: </bold>To report three cases of cardiotoxicity related to the administration of 5-fluorouracil (5-FU) in patients with cancer.<bold>Clinical Features: </bold>Three patients with gastrointestinal malignancies were being treated with combined radiotherapy and chemotherapy regimens. Two patients developed myocardial ischaemia and the other a ventricular arrhythmia in association with 5-FU administration.<bold>Intervention and Outcome: </bold>All patients survived the cardiac event. No patient was rechallenged with 5-FU. Radiotherapy was continued, achieving a good tumour response.<bold>Conclusion: </bold>Cardiotoxicity is rarely reported with 5-FU. The cardiac events can be life threatening. It is difficult to predict which patients will be affected. Clinicians need to be aware of this potential toxicity and monitor patients appropriately.
- Publication
Medical Journal of Australia, 1994, Vol 161, Issue 3, p207
- ISSN
0025-729X
- Publication type
journal article
- DOI
10.5694/j.1326-5377.1994.tb127384.x