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- Title
1,3,4-Thiadiazol-2-amine Derivatives as Urotensin- II Receptor ( UT) Antagonists.
- Authors
Lim, Chae Jo; Jang, Ju Young; Kim, Sung Hwan; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang
- Abstract
The article focuses on a research on 1,3,4-Thiadiazol-2-amine derivatives as urotensin-II receptor (UT) antagonists. It states that urotensin-II (U-II) is the most potent of all vasoconstrictors which involved in the regulation of cardiovascular functions. It mentions that replacement of the phenylurea group with aminobenzyl group was expected to provide an interaction with U-II receptor and synthesis is carried out of biological evaluation and structure-activity relationship (SAR) study.
- Subjects
UROTENSINS; VASOCONSTRICTORS; CARDIOVASCULAR system; PHENYLUREA compounds; THIADIAZOLES; THERAPEUTICS
- Publication
Bulletin of the Korean Chemical Society, 2015, Vol 36, Issue 10, p2549
- ISSN
0253-2964
- Publication type
Article
- DOI
10.1002/bkcs.10475