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- Title
Advanced Glycation End Products in Human Cancer Tissues/Detection of Nε-(Carboxymethyl)lysine and Argpyrimidine.
- Authors
HEIJST, JEROEN W. J.; NIESSEN, HANS W. M.; HOEKMAN, KLAAS; SCHALKWIJK, CASPER G.
- Abstract
Tumors are generally characterized by an increased glucose uptake and a high rate of glycolysis. Since one consequence of an elevated glycolysis is the nonenzymatic glycation of proteins, we studied the presence of advanced glycation end products (AGEs) in human cancer tissues. We detected the presence of the AGEs Nε-(carboxymethyl)lysine (CML) and argpyrimidine in several human tumors using specific antibodies. Because AGEs have been associated with the etiology of a variety of different diseases, these results suggest that CML and argpyrimidine could be implicated in the biology of human cancer.
- Subjects
TUMORS; GLUCOSE; GLYCOLYSIS; CANCER cells; IMMUNOGLOBULINS
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1043, Issue 1, p725
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1333.084