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- Title
Cortical and Subcortical Brain Area Atrophy in SCA1 and SCA2 Patients in India: The Structural MRI Underpinnings and Correlative Insight Among the Atrophy and Disease Attributes.
- Authors
Tamuli, Dibashree; Kaur, Manpreet; Sethi, Tavpritesh; Singh, Anup; Faruq, Mohammed; Jaryal, Ashok; Srivastava, Achal; Kumaran, Senthil; Deepak, Kishore; Jaryal, Ashok K; Srivastava, Achal K; Kumaran, Senthil S; Deepak, Kishore K
- Abstract
<bold>Introduction: </bold>Genetically defined spinocerebellar ataxia (SCA) type 1 and 2 patients have differential clinical profile along with probable distinctive cortical and subcortical neurodegeneration. We compared the degree of brain atrophy in the two subtypes with their phenotypic and genotypic parameters.<bold>Methods: </bold>MRI was performed using a 3T scanner (Philips, Achieva) to obtain 3D T1-weighted scans of the whole brain and analyzed by FreeSurfer (version 5.3 and 6 dev.) software. Genetically proven SCA1 (n = 18) and SCA2 (n = 25) patients with age-matched healthy controls (n = 8) were recruited. Clinical severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). To know the differential pattern of atrophy, the groups were compared using ANOVA/Kruskal-Wallis test and followed by correlation analysis with multiple corrections. Further, machine learning-based classification of SCA subtypes was carried out.<bold>Result: </bold>We found (i) bilateral frontal, parietal, temporal, and occipital atrophy in SCA1 and SCA2 patients; (ii) reduced volume of cerebellum, regions of brain stem, basal ganglia along with the certain subcortical areas such as hippocampus, amygdala, thalamus, diencephalon, and corpus callosum in SCA1 and SCA2 subtypes; (iii) higher subcortical atrophy SCA2 than SCA1 (iv) correlation between brain atrophy and disease attributes; (v) differential predictive pattern of two SCA subtypes using machine learning approach.<bold>Conclusion: </bold>The present study suggests that SCA1 and SCA2 do not differ in cortical thinning while a characteristic pattern of subcortical atrophy SCA2 > SCA1 is observed along with correlation of brain atrophy and disease attributes. This may provide the diagnostic guidance of MRI to SCA subtypes and differential therapies.
- Subjects
BRAIN; MAGNETIC resonance imaging; ATROPHY; CEREBELLUM; SPINOCEREBELLAR ataxia
- Publication
Neurology India, 2021, Vol 69, Issue 5, p1318
- ISSN
0028-3886
- Publication type
journal article
- DOI
10.4103/0028-3886.329596